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KMID : 0359920080270060712
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Korean Journal of Nephrology
2008 Volume.27 No. 6 p.712 ~ p.719
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The Effect of Uric Acid on GFR in Early Period after Kidney Transplantation
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Park Sun-Young
Kim Dong-Ki
Chang Jae-Hyun
Kim Hyun-Wook
Kim Eun-Young
Park Jung-Tak
Chang Tae-Ik
Yoo Tae-Hyun
Kim Beom-Seok
Kang Shin-Wook
Lee Ho-Yung
Han Dae-Suk
Kim Myoung-Soo
Kim Soon-Il
Choi Kyu-Hun
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Abstract
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Purpose: Hyperuricemia is a common complication occurring shortly after kidney transplantation. Although increased uric acid level is a risk factor for cardiovascular disease and mortality, the relationship between uric acid level and graft function after transplantation has been a controversial issue. Therefore, we investigated the effects of uric acid on glomerular filtration rate (GFR) and graft survival in the early periods of kidney transplantation.
Methods: Data were collected from 245 patients who underwent kidney transplantation between 2002 and 2004 at Yonsei University Medical Center. Uric acid level and estimated GFR were measured monthly during the first 6 months and then yearly for 3 years.
Results: The mean age of the study population was 40.2±11.7 years. The proportion of patients with hyperuricemia (uric acid ≥6.8 mg/dL) showed increment during the 3 year follow up. Increased serum uric acid level showed a negative correlation with estimated GFR during the initial 6 monthsm after transplantation (r=-0.026, p<0.05). In Kaplan-Meier analysis, patients with a mean uric acid level higher than 6.8 mg/dL during the first 6 months showed a lower cumulative graft survival during the consecutive 3 years compared to patients with a uric acid level lower than 6.8 mg/dL (HR 1.7, p=0.003).
Conclusion: Uric acid levels were associated with the changes of GFR in the initial 6 months of kidney transplantation, and the hyperuricemia during the early stages of transplantation might influence the long term graft survival.
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KEYWORD
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Uric acid, Kidney transplantation, Glomerular filtration rate
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